i have 4 great danes, two of them suffer once or twice the year under sarcoptic mange outbrake. i tried whatever i coulf find - from neem oil to frontline plus and nothing helped. since two years i'm using advocate and to my (and the dogs) great relive it works, after one app they stop scraching and in the second month they look quite normal. advantage multi is the same product. if you have a dog with sarcoptic mange, give it a try !